The story of New Jersey-based Italian-American mobster Tony Soprano and the difficulties he faces as he tries to balance the conflicting requirements of his home life and the criminal organization he heads. Those difficulties are often highlighted through his ongoing professional relationship with psychiatrist Jennifer Melfi. The show features Tony's family members and Mafia associates in prominent roles and story arcs, most notably his wife Carmela and his cousin and protégé Christopher Moltisanti.
Set in the changing world of the late 1960s, Susanna Kaysen's prescribed "short rest" from a psychiatrist she had met only once becomes a strange, unknown journey into Alice's Wonderland, where she struggles with the thin line between normal and crazy. Susanna soon realizes how hard it is to get out once she has been committed, and she ultimately has to choose between the world of people who belong inside or the difficult world of reality outside.
When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.
Telly Paretta is a grieving mother struggling to cope with the loss of her 8-year-old son. She is stunned when her psychiatrist reveals that she has created eight years of memories about a son she never had. But when she meets a man who has had a similar experience, Telly embarks on a search to prove her son's existence, and her sanity.
Beth, Calvin, and their son Conrad are living in the aftermath of the death of the other son. Conrad is overcome by grief and misplaced guilt to the extent of a suicide attempt. He is in therapy. Beth had always preferred his brother and is having difficulty being supportive to Conrad. Calvin is trapped between the two trying to hold the family together.
An arrogant, high-powered attorney takes on the case of a poor altar boy found running away from the scene of the grisly murder of the bishop who has taken him in. The case gets a lot more complex when the accused reveals that there may or may not have been a third person in the room.
Hector is a quirky psychiatrist who has become increasingly tired of his humdrum life. As he tells his girlfriend, Clara, he feels like a fraud: he hasn’t really tasted life, and yet he’s offering advice to patients who are just not getting any happier. So Hector decides to break out of his deluded and routine driven life. Armed with buckets of courage and child-like curiosity, he embarks on a global quest in hopes of uncovering the elusive secret formula for true happiness. And so begins a larger than life adventure with riotously funny results.
Prot is a patient at a mental hospital who claims to be from a far away planet. His psychiatrist tries to help him, only to begin to doubt his own explanations.
Sibyl, a jaded psychotherapist, returns to her first passion: writing. But her newest patient Margot, a troubled up-and-coming actress, proves to be a source of inspiration that is far too tempting. Fascinated almost to the point of obsession, Sibyl becomes more and more involved in Margot’s tumultuous life, reviving volatile memories that bring her face to face with her past.
Aspiring to an easy job as personal physician to a wealthy family, Noboru Yasumoto is disappointed when his first post after medical school takes him to a small country clinic under the gruff doctor Red Beard. Yasumoto rebels in numerous ways, but Red Beard proves a wise and patient teacher. He gradually introduces his student to the unglamorous side of the profession, ultimately assigning him to care for a prostitute rescued from a local brothel.