Two New Orleans paramedics' lives are ripped apart after encountering a series of horrific deaths linked to a designer drug with bizarre, otherworldly effects.
Chris and his girlfriend Rose go upstate to visit her parents for the weekend. At first, Chris reads the family's overly accommodating behavior as nervous attempts to deal with their daughter's interracial relationship, but as the weekend progresses, a series of increasingly disturbing discoveries lead him to a truth that he never could have imagined.
When a 10-year-old boy goes missing, lead investigator Greg Harper struggles to balance the pressure of the investigation and troubles with his wife, Jackie. Facing a recent affair, great strain is put on the family that slowly gnaws away at Jackie's grip on reality. But after a malicious presence manifests itself in their home and puts their son, Connor, in mortal danger, the cold, hard truth about evil in the Harper household is finally uncovered.
A family vacation takes a terrifying turn when parents Paul and Wendy discover their young daughter has vanished without a trace. Stopping at nothing to find her, the search for the truth leads to a shocking revelation.
In 1965 New England, a troubled girl encounters mysterious happenings in the woods surrounding an isolated girls school that she was sent to by her estranged parents.
Plagued by frightening occurrences in their home, Kelly and Ben learn that a university's parapsychology experiment produced an entity that is now haunting them. The malevolent spirit feeds on fear and torments the couple no matter where they run. Desperate, Kelly and Ben turn to a paranormal researcher, but even with his aid, it may already be too late to save themselves from the terrifying presence.
When elderly mother Edna inexplicably vanishes, her daughter rushes to the family's decaying home, finding clues of her increasing dementia scattered around the house in her absence.
Minami mistakenly kills a gangster associate of his named Brother. Almost as soon as the murder takes place, the body of the deceased man is gone, prompting Minami to conduct a search. While looking, he finds a mysterious isolated hotel where he decides to take a rest. Not only are the front desk clerks a bit strange, but even the ambiance feels unusual. Minami soon realizes he may have gotten more than he bargained for.
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