Georges has Down syndrome, living at a mental-institution, Harry is a busy businessman, giving lectures for young aspiring salesmen. He is successful in his business life, but his social life is a disaster since his wife left him and took their two children with her. This weekend his children came by train to meet him, but Harry, working as always, forgot to pick them up. Neither his wife or his children want to see him again and he is driving around on the country roads, anguished and angry. He almost runs over Georges, on the run from the institution since everybody else went home with their parents except him, whose mother is dead. Harry tries to get rid of Georges but he won't leave his new friend. Eventually a special friendship forms between the two of them, a friendship which makes Harry a different person.
Calvin Campbell is a former professional baseball player sent to an early retirement due to his panic attacks at the plate. Even though he had all the talent for the big leagues, he struggles with the curveballs life has thrown him. Today, he mindlessly sleepwalks through his days and the challenge of raising his teenager daughter. His life is in a slow downward spiral when it is suddenly awakened and invigorated by the most unlikely person – Produce, a young-man with Down syndrome who works at the local grocery store.
A down-on-his-luck crab fisherman embarks on a journey to get a young man with Down syndrome to a professional wrestling school in rural North Carolina and away from the retirement home where he’s lived for the past two and a half years.
During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.
In the late 1970s, when a mentally handicapped teenager is abandoned, a gay couple takes him in and becomes the family he's never had. But once the unconventional living arrangement is discovered by authorities, the men must fight the legal system to adopt the child.
Jacqueline is a young mother living in 1960s Paris with her disabled son Laurent. Abandoned by her husband, Jacqueline sacrifices everything to care for her son and vows to give Laurent a “normal” life full of happiness. Antoine, is a successful DJ in present day Montreal who seems to have it all: a thriving career, two beautiful daughters, partner Rose, with whom he is passionately in love. However, nothing is perfect and Antoine’s ex-wife Carole remains devastated by their recent separation.
Astrid is a comedian who makes people laugh for a living; her husband Markus is her manager and the two of them work well together. They have a nine-year-old daughter and are expecting their second child. When they learn that their child will not be born healthy, they are at first optimistic that they will be able to meet this challenge – although they have no idea what awaits them. But the closer it gets to the due date, the more Astrid begins to worry about the future of her unborn child as well as that of her family and her career. After many discussions and arguments Astrid realises that the decision that will affect all their lives must be made by her alone. What complicates matters further is the fact that, as a successful entertainer, she is in the eye of the public and the media.
Alba has Down's Syndrome and was left in the hospital when she was born. Thirty families rejected her before the court decided to entrust her to Luca: a Catholic — and gay — single man.
Dafne has recently lost her mother – and Luigi his wife – in an accident. But whilst this 30-year-old, who was born with Down’s syndrome, is still managing to master her life with verve after the terrible disaster, her father sinks into a depression. It will take all the energy Dafne can muster to help him get back on his feet. Fortunately, headstrong Dafne happens to have a lot of it up her sleeve.
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