Five teenage friends set out for the beach on their Spring Break vacation. Good times are cut short when one of the group, Carrie, contracts a deadly sexual transmitted disease during a bathroom stop. When they stop for the night at an isolated motel, the real terror begins when the STD virus starts running rampant, turning those infected into the living dead.
Return to Horror Hotel is an anthology feature with 4 segments. One is about giant a bedbugs, one is about a magical charm that turns girls beautiful, one is about a WWII sailor who hasn't aged and one is about a terrorizing severed hand.