Patagonia narrates the journeys of two women - one looking for her past, the other for her future. The film inter-cuts between their stories, in which one of them travels south to north through the Welsh springtime and the other east to west through the Argentine autumn.
Throughout his life Edward Bloom has always been a man of big appetites, enormous passions and tall tales. In his later years, he remains a huge mystery to his son, William. Now, to get to know the real man, Will begins piecing together a true picture of his father from flashbacks of his amazing adventures.
Wyatt and Billy, two Harley-riding hippies, complete a drug deal in Southern California and decide to travel cross-country in search of spiritual truth.
Jack is caught with the wife of his employer, a Vegas thug. The thug sends goons after Jack, who convinces his best friend, Pilot, to flee with him. Pilot insists that they head for Seattle, but doesn't tell Jack why. The goons learn from Pilot's drug source where the youths are headed, and they follow, hell bent on breaking Jack's feet. On the road, Jack and Pilot give a ride to Cassie, a distressed young woman. She and Jack hit it off. They pick up an aging stoner headed to Seattle for Kurt Cobain's memorial, and they help a circus sideshow family. Why is Pilot so set on Seattle, will the goons catch Jack, and is there any way the friends' competing needs can be resolved?