The story revolves around a Basque Roman Catholic priest dedicated to committing as many sins as possible, a death metal salesman from Carabanchel, and the Italian host of a TV show on the occult. These go on a literal "trip" through Christmas-time Madrid to hunt for and prevent the reincarnation of the Antichrist.
Three robbers on the run to a new life cross their way with a woman and her son and with the tragic curse they're bringing. On their trail, the mob boss they worked for and a mysterious secret organization of unscrupulous men. During this crazy epic ride to hell, a jealous girlfriend and an former-cop and his brisk methods will join them. At stake, the child's life and the future of the world.