Naples, 18th century. Salvatore "Totò" Sapore, an unemployed minstrel, always manages to cheer up the hungry with his songs about good food, always upsetting Vesuvia, a magma witch who lives inside the Vesuvius.
After the defeat of their old arch nemesis, The Shredder, the Turtles have grown apart as a family. Struggling to keep them together, their rat sensei, Splinter, becomes worried when strange things begin to brew in New York City.