Two seriously wounded samurai find refuge from a storm at an isolated temple, the home of a swordsman and a mysterious young woman. One samurai awakes to find that not only has his comrade died, but that his wounds have miraculously healed. He discovers that he has been given the power of immortality by the swordsman, a man once known as the legendary Miyamoto Musashi, who now lives an endless existence as Aragami, a "god of battle".
Ash, a handsome, shotgun-toting, chainsaw-armed department store clerk, is time warped backwards into England's Dark Ages, where he romances a beauty and faces legions of the undead.
A rare mutation has occurred within the vampire community - The Reaper. A vampire so consumed with an insatiable bloodlust that they prey on vampires as well as humans, transforming victims who are unlucky enough to survive into Reapers themselves. Blade is asked by the Vampire Nation for his help in preventing a nightmare plague that would wipe out both humans and vampires.