A collection of artifacts from an archeological dig in Egypt are brought to the famous Louvre museum in Paris, and while experts are using a laser scanning device to determine the age of a sarcophagus, a ghostly spirit escapes and makes its way into the museum's electrical system.
Though safely entombed in a crypt deep beneath the unforgiving desert, an ancient queen whose destiny was unjustly taken from her is awakened in our current day, bringing with her malevolence grown over millennia, and terrors that defy human comprehension.
An ancient Egyptian priest named Imhotep is revived when an archaeological expedition finds his mummy and one of the archaeologists accidentally reads an ancient life-giving spell. Imhotep escapes from the field site and searches for the reincarnation of the soul of his lover.
Bubba Ho-tep tells the "true" story of what really did become of Elvis Presley. We find Elvis as an elderly resident in an East Texas rest home, who switched identities with an Elvis impersonator years before his "death," then missed his chance to switch back. He must team up with JFK and fight an ancient Egyptian mummy for the souls of their fellow residents.