A young boy, Alfred, is dying, but through the stories about Helium, a magical fantasy world, told by the hospital's eccentric janitor, Enzo, Alfred regains the joy and happiness of his life, and finds a safe haven away from daily life.
Outsider and new kid Matthew desperately wants to join his high school's boxing team, but resident bully and boxing champion Hector stands in his way. Facing constant torment, Matthew finds an unlikely ally in Dan, the school's janitor and one-time amateur boxer. Together, they train for the biggest boxing match of Matthew's life and discover what it truly means to be a winner.
Erik, a loner, finds a friend in Dexter, an eleven-year-old boy with AIDS. They vow to find a cure for AIDS together and save Dexter's life in an eventful summer.
Told in flashback from the perspective of Megan, the storyline unfolds when her commitment to faith and family is renewed after reading the blog of Julie Locke, the online journal that Julie kept after her 13 months old Dax was diagnosed with Acute Myeloid Leukemia (AML).
When Gabriel, a 7-year-old Chinese kid who loves ballet, becomes friends with Rob, another Chinese kid from school, Rob’s dad gets suspicious about Gabriel's feminine behavior and decides to intervene.
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