Liliana is the dream girl of many of her co-workers, among them "Piquiña", an ugly and ordinary charlatan who, convinced of his irresistible attractiveness, launches into her conquest during the celebration of the company's "novena". Liliana, who can't stand "Piquíña", makes it clear to him that the only way she would be with him would be if he were the last man on earth.
Jack's lavish, fast-paced lifestyle changes one Christmas night when he stumbles into a grocery store holdup and disarms the gunman. The next morning he wakes up in bed lying next to Kate, his college sweetheart he left in order to pursue his career, and to the horrifying discovery that his former life no longer exists. As he stumbles through this alternate suburban universe, Jack finds himself at a crossroad where he must choose between his high-power career and the woman he loves.
London publicist Helen, effortlessly slides between parallel storylines that show what happens when she does or does not catch a train back to her apartment. Love. Romantic entanglements. Deception. Trust. Friendship. Comedy. All come into focus as the two stories shift back and forth, overlap and surprisingly converge.
IRS auditor Harold Crick suddenly finds his mundane Chicago life to be the subject of narration only he can hear: narration that begins to affect his entire existence, from his work to his love life to his death.