"Golpe de Suerte" tells the lives of three families from different social classes. First there are the Pérez Flores, who live in Neza and are made up of Ignacio, Julia and their children Ronaldo and Wendy. The second family is made up of Miranda Ortiz and her little son Diego; They live in the Roma neighborhood in the house of César Traven, a generous elderly antiques dealer. And finally there are Brenda Uriarte, her brother Tony, her stepmother Constanza and her stepsister Sabrina, an upper middle class family. Each of these families will experience a radical change in their lives the day they win two hundred million pesos.
Paz Roble, a kind, hard-working and honest woman from whom her husband, Fermín, takes her newborn daughter. Fermín has a large debt with some lenders and to pay it he decides to sell his daughter to Mauro Nicoliti. This plagiarism is orchestrated by Geneva, Mauro's adoptive sister. She lost her first-born daughter in childbirth and does everything to replace her dead daughter and keep her husband's fortune. On the other hand, Esteban Villa de Cortés loses his wife and becomes a widower with his three children. Elvira Moncada, Esteban's mother-in-law, holds him responsible for the death of her daughter. After a series of unexpected events, Esteban and Paz meet in the neighborhood where she lives with her family. The chemistry and great understanding that exists between them makes it inevitable that they will fall in love.