The inhabitants of the British Isles have lost their battle against the onslaught of disease, as the deadly rage virus has killed every citizen there. Six months later, a group of Americans dare to set foot on the isles, convinced the danger has come and gone. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.
Lured by the promise of an Australian holiday, backpackers Rutger, Katarina and Paul visit the notorious Wolf Creek Crater. Their dream Outback adventure soon becomes a horrific reality when they encounter the site's most infamous local, the last man any traveller to the region ever wants to meet—Mick Taylor. As the backpackers flee, Mick pursues them on an epic white knuckled rampage across hostile wasteland.
A group of six tourists looking to go off the beaten path, hire an 'extreme tour guide' who, ignoring warnings, takes them into the city of Pripyat, the former home to the workers of the Chernobyl nuclear reactor, but now a deserted town since the disaster more than 25 years earlier. After a brief exploration of the abandoned city, the group members find themselves stranded, only to discover that they are not alone.
When a group of tourists stumble into the remote Australian river territory of an enormous crocodile, the deadly creature traps them on a tiny mud island with the tide quickly rising and darkness descending. As the hungry predator closes in, they must fight for survival against all odds.
A group of young backpackers' vacation turns sour when a bus accident leaves them marooned in a remote Brazilian rural area that holds an ominous secret.
During a stormy night in the Scottish Highlands, two criminal brothers on the run seek refuge in a desolate farmhouse. But after taking the resident family captive, they find the house holds even darker secrets of its own.
Six members of a media company go on a weekend business retreat at an isolated lodge in the woods. When one of the members goes missing, they discover that the lodge was formerly a private mental institution that had been shut down after allegations of devious misconduct. One by one, they fall victim to the dark secrets buried at the lodge.
A group of American tourists heading down an African river make a brief stop at Snake Island, an island that has been virtually abandoned for years. When they end up getting trapped on the island overnight, they find thousands of deadly snakes intent on reclaiming the tropical island for themselves.