In late 1890s Wyoming, Butch Cassidy is the affable, clever and talkative leader of the outlaw Hole in the Wall Gang. His closest companion is the laconic dead-shot Sundance Kid. As the west rapidly becomes civilized, the law finally catches up to Butch, Sundance and their gang. Chased doggedly by a special posse, the two decide to make their way to South America in hopes of evading their pursuers once and for all.
Oregon, 1851. Hermann Kermit Warm, a chemist and aspiring gold prospector, keeps a profitable secret that the Commodore wants to know, so he sends the Sisters brothers, two notorious assassins, to capture him on his way to California.
Maverick is a gambler who would rather con someone than fight them, and needs an additional three thousand dollars in order to enter a winner-takes-all poker game that begins in a few days, so he joins forces with a woman gambler with a marvellous southern accent, and the two try and enter the game.