Shaun Murphy, a young surgeon with autism and savant syndrome, relocates from a quiet country life to join a prestigious hospital's surgical unit. Unable to personally connect with those around him, Shaun uses his extraordinary medical gifts to save lives and challenge the skepticism of his colleagues.
Following his father's death, Shaun must deal with the effects his intimacy with Lea will have on his relationship with Carly; the team operates on a patient who is refusing all anesthesia during surgery for fear of relapsing.