Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
The team learns that their 14-year-old patient is suffering from more than teen angst when her physical symptoms worsen. Despite Foreman’s firm opposition, House becomes obsessed with solving a peculiar case of a deceased four-year-old patient, which gets him into serious trouble. Meanwhile, Park tries to get Chase to admit the reason behind his recent obsession with grooming.