Dr. Gregory House, a drug-addicted, unconventional, misanthropic medical genius, leads a team of diagnosticians at the fictional Princeton–Plainsboro Teaching Hospital in New Jersey.
The team must treat an agoraphobic who refuses to leave his house, and have to work around Cuddy, who is less than thrilled at having hospital equipment relocated. Meanwhile, House is plagued by an itch, and Cameron and Chase have relationship issues.