Walter White, a New Mexico chemistry teacher, is diagnosed with Stage III cancer and given a prognosis of only two years left to live. He becomes filled with a sense of fearlessness and an unrelenting desire to secure his family's financial future at any cost as he enters the dangerous world of drugs and crime.
Walt and Jesse are vividly reminded of Tuco’s volatile nature, and try to figure a way out of their business partnership. Hank attempts to mend fences between the estranged Marie and Skyler.
Walt and Jesse find themselves in close quarters with an unhinged Tuco. Marie and Hank comfort Skyler, who is distraught over Walt’s disappearance. Hank pays a visit to Mrs. Pinkman on some not-so-official business.
Jesse and Walt discuss expanding into new territories; Hank struggles to fit in; Skyler pursues a new job opportunity; Jesse gets to know his landlord.
Walt and Jesse seek advice from a shady attorney when Badger gets in trouble with the law; the DEA believes they have caught up with "Heisenberg" ; Hank returns.
Walt and his family wait for news after he undergoes a PET-CT scan. Walt follows Saul's advice; Jesse's relationship with Jane is put on hold when he and Walt head to the desert for a marathon of cooking.
As Walt explores money laundering options, he and Jesse spar over the profits from their latest deal. Jesse and Jane clash with her father. Walt makes a fatal decision.